Multiple Self-Healing Palmoplantar Carcinoma: A Familial Predisposition to Skin Cancer with Primary Palmoplantar and Conjunctival Lesions

PDL reduces the PDT light dose required to achieve persistent vascular shutdown, even at low PDL radiant exposures. We hypothesize that TS-mediated PDT enhances persistent vascular shutdown achieved with ensuing PDL therapy, primarily via endothelial cell damage (Mitra and Foster, 2008); mechanistic studies currently are underway. Dual phototherapy represents a potential new approach for more effective treatment of PWS birthmarks. We have initiated a trial approved by the Investigational Review Board to evaluate intravenously administered TS/664-nm laser light–mediated dual phototherapy for PWS treatment. Treatment has been painless and notable lesion lightening has been achieved with both PDT and PDTþPDL in a single session. Patients are photosensitive for 5–7 days post procedure, and for the first 72hours they must remain indoors with lights dimmed. Completion of this study will determine whether lesion lightening is greater with dual phototherapy than PDL alone. It is our intent that this combined low-energy dual phototherapy will offer clinicians and patients of all skin types improved lesion lightening in fewer treatments.